At Cardiff’s City Hall, Mr Davis addressed 400 business leaders after spending the day visiting business in south Wales.
Mr Davis said: “In exit we are not seeking a bitter divorce, but a better relationship. That’s the government’s ambition.
“So my request to you, leaders of industry here in Wales and across the whole of the UK, is a straightforward one. Help us to write this new and exciting chapter in the country’s history.
“Our challenge is to navigate a period of inevitable uncertainty with cool heads and a united sense of purpose and confidence.
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“Suggestions that the UK might somehow reverse its decision aren’t just misleading, they risk undermining our negotiating position and adding to uncertainty.
“And a second referendum would give those on the other side in the negotiations an incentive to give us the worst possible deal to try to force the British people to change their minds.”
Also in attendance was secretary of state for Wales Alun Cairns, who said: “We are facing both challenges and opportunities following Brexit.
“We will deliver a deal that ensures our exit from the EU will be a success for the whole of the UK, including Wales.
“The Welsh economy is in good shape for the road ahead and remains fundamentally strong, highly competitive and open for business.”
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